Zinc, Metallothioneins, and Longevity:
Identifieur interne : 000606 ( Main/Exploration ); précédent : 000605; suivant : 000607Zinc, Metallothioneins, and Longevity:
Auteurs : Eugenio Mocchegiani [Italie] ; Robertina Giacconi [Italie] ; Catia Cipriano [Italie] ; Laura Costarelli [Italie] ; Elisa Muti [Italie] ; Silvia Tesei [Italie] ; Cinzia Giuli [Italie] ; Roberta Papa [Italie] ; Fiorella Marcellini [Italie] ; Erminia Mariani [Italie] ; Lothar Rink [Allemagne] ; George Herbein [France] ; Audrey Varin [France] ; Tamas Fulop [Canada] ; Daniela Monti [Italie] ; Jolanta Jajte [Pologne] ; George Dedoussis [Grèce] ; Efstathios S. Gonos [Grèce] ; Ioannis P. Trougakos [Grèce] ; Marco Malavolta [Italie]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2007-11.
English descriptors
- KwdEn :
Abstract
Abstract: Aging is an inevitable biological process that is associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Because nutritional factors are involved in improving immune functions, metabolic harmony, and antioxidant defense, some nutritional factors, such as zinc, may modify susceptibility to disease and promote healthy aging. In vitro (human lymphocytes exposed to endotoxins) and in vivo (old or young mice fed with low zinc dietary intake) studies revealed that zinc is important for immune efficiency (innate and adaptive), antioxidant activity (supeoxide dismutase), and cell differentiation via clusterin/apolipoprotein J. Intracellular zinc homeostasis is regulated by metallothioneins (MT) via ion release through the reduction of thiol groups in the MT molecule. This process is crucial in aging because high MT levels are not able to release zinc, resulting in low intracellular free ion availability for biological functions. Improvement in these functions occurs in the elderly after physiological zinc supplementation. In this study, the selection of elderly subjects for zinc supplementation is discussed in relation to the genetic background of MT and pro‐inflammatory cytokines, such as interleukin‐6, because the latter is involved both in MT‐gene expression and in intracellular zinc homeostasis.
Url:
DOI: 10.1196/annals.1404.030
Affiliations:
- Allemagne, Canada, France, Grèce, Italie, Pologne
- Bourgogne-Franche-Comté, District de Cologne, Franche-Comté, Rhénanie-du-Nord-Westphalie
- Aix-la-Chapelle, Besançon
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Immunosenescence), Research Department, Italian National Research Center on Aging (INRCA), Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Cipriano, Catia" sort="Cipriano, Catia" uniqKey="Cipriano C" first="Catia" last="Cipriano">Catia Cipriano</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology Center (Section: Nutrigenomic and Immunosenescence), Research Department, Italian National Research Center on Aging (INRCA), Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Costarelli, Laura" sort="Costarelli, Laura" uniqKey="Costarelli L" first="Laura" last="Costarelli">Laura Costarelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology Center (Section: Nutrigenomic and Immunosenescence), Research Department, Italian National Research Center on Aging (INRCA), 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Cinzia" uniqKey="Giuli C" first="Cinzia" last="Giuli">Cinzia Giuli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontological and Psychological Center, Research Department, INRCA, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Papa, Roberta" sort="Papa, Roberta" uniqKey="Papa R" first="Roberta" last="Papa">Roberta Papa</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontological and Psychological Center, Research Department, INRCA, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Marcellini, Fiorella" sort="Marcellini, Fiorella" uniqKey="Marcellini F" first="Fiorella" last="Marcellini">Fiorella Marcellini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontological and Psychological Center, Research Department, INRCA, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Mariani, Erminia" sort="Mariani, Erminia" uniqKey="Mariani E" first="Erminia" last="Mariani">Erminia Mariani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Immunology and Genetics, Istituto di Ricerca Codivilla Putti IOR, Bologna and Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Rink, Lothar" sort="Rink, Lothar" uniqKey="Rink L" first="Lothar" last="Rink">Lothar Rink</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Immunology, RWTH‐Aachen University Hospital, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Herbein, George" sort="Herbein, George" uniqKey="Herbein G" first="George" last="Herbein">George Herbein</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department. of Virology, Franche‐Comte University, Besancon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Varin, Audrey" sort="Varin, Audrey" uniqKey="Varin A" first="Audrey" last="Varin">Audrey Varin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department. of Virology, Franche‐Comte University, Besancon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamas" last="Fulop">Tamas Fulop</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Research Center on Aging, Immunology Program, Geriatric Division, University of Sherbrooke, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Monti, Daniela" sort="Monti, Daniela" uniqKey="Monti D" first="Daniela" last="Monti">Daniela Monti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental Pathology and Oncology, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Jajte, Jolanta" sort="Jajte, Jolanta" uniqKey="Jajte J" first="Jolanta" last="Jajte">Jolanta Jajte</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Toxicology, Faculty of Pharmacy, Medical University, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Gonos, Efstathios S" sort="Gonos, Efstathios S" uniqKey="Gonos E" first="Efstathios S." last="Gonos">Efstathios S. Gonos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, Institute National Hellenic Research Foundation, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Trougakos, Ioannis P" sort="Trougakos, Ioannis P" uniqKey="Trougakos I" first="Ioannis P." last="Trougakos">Ioannis P. Trougakos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, Institute National Hellenic Research Foundation, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Malavolta, Marco" sort="Malavolta, Marco" uniqKey="Malavolta M" first="Marco" last="Malavolta">Marco Malavolta</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology Center (Section: Nutrigenomic and Immunosenescence), Research Department, Italian National Research Center on Aging (INRCA), Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2007-11">2007-11</date><biblScope unit="volume">1119</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="129">129</biblScope><biblScope unit="page" to="146">146</biblScope></imprint><idno type="ISSN">0077-8923</idno></series><idno type="istex">BD4EE3D6C4FE4936F1543BF2669E089CAD450458</idno><idno type="DOI">10.1196/annals.1404.030</idno><idno type="ArticleID">NYAS1119030</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>aging, longevity</term><term>antioxidant activity</term><term>genetic screening</term><term>immune response</term><term>metallothioneins</term><term>zinc</term><term>zinc supplementation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Abstract: Aging is an inevitable biological process that is associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Because nutritional factors are involved in improving immune functions, metabolic harmony, and antioxidant defense, some nutritional factors, such as zinc, may modify susceptibility to disease and promote healthy aging. In vitro (human lymphocytes exposed to endotoxins) and in vivo (old or young mice fed with low zinc dietary intake) studies revealed that zinc is important for immune efficiency (innate and adaptive), antioxidant activity (supeoxide dismutase), and cell differentiation via clusterin/apolipoprotein J. Intracellular zinc homeostasis is regulated by metallothioneins (MT) via ion release through the reduction of thiol groups in the MT molecule. This process is crucial in aging because high MT levels are not able to release zinc, resulting in low intracellular free ion availability for biological functions. Improvement in these functions occurs in the elderly after physiological zinc supplementation. In this study, the selection of elderly subjects for zinc supplementation is discussed in relation to the genetic background of MT and pro‐inflammatory cytokines, such as interleukin‐6, because the latter is involved both in MT‐gene expression and in intracellular zinc homeostasis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li></country><region><li>Bourgogne-Franche-Comté</li><li>District de Cologne</li><li>Franche-Comté</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li><li>Besançon</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Mocchegiani, Eugenio" sort="Mocchegiani, Eugenio" uniqKey="Mocchegiani E" first="Eugenio" last="Mocchegiani">Eugenio Mocchegiani</name></noRegion><name sortKey="Cipriano, Catia" sort="Cipriano, Catia" uniqKey="Cipriano C" first="Catia" last="Cipriano">Catia Cipriano</name><name sortKey="Costarelli, Laura" sort="Costarelli, Laura" uniqKey="Costarelli L" first="Laura" last="Costarelli">Laura Costarelli</name><name sortKey="Giacconi, Robertina" sort="Giacconi, Robertina" uniqKey="Giacconi R" first="Robertina" last="Giacconi">Robertina Giacconi</name><name sortKey="Giuli, Cinzia" sort="Giuli, Cinzia" uniqKey="Giuli C" first="Cinzia" last="Giuli">Cinzia Giuli</name><name sortKey="Malavolta, Marco" sort="Malavolta, Marco" uniqKey="Malavolta M" first="Marco" last="Malavolta">Marco Malavolta</name><name sortKey="Marcellini, Fiorella" sort="Marcellini, Fiorella" uniqKey="Marcellini F" first="Fiorella" last="Marcellini">Fiorella Marcellini</name><name sortKey="Mariani, Erminia" sort="Mariani, Erminia" uniqKey="Mariani E" first="Erminia" last="Mariani">Erminia Mariani</name><name sortKey="Monti, Daniela" sort="Monti, Daniela" uniqKey="Monti D" first="Daniela" last="Monti">Daniela Monti</name><name sortKey="Muti, Elisa" sort="Muti, Elisa" uniqKey="Muti E" first="Elisa" last="Muti">Elisa Muti</name><name sortKey="Papa, Roberta" sort="Papa, Roberta" uniqKey="Papa R" first="Roberta" last="Papa">Roberta Papa</name><name sortKey="Tesei, Silvia" sort="Tesei, Silvia" uniqKey="Tesei S" first="Silvia" last="Tesei">Silvia Tesei</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Rink, Lothar" sort="Rink, Lothar" uniqKey="Rink L" first="Lothar" last="Rink">Lothar Rink</name></region></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Herbein, George" sort="Herbein, George" uniqKey="Herbein G" first="George" last="Herbein">George Herbein</name></region><name sortKey="Varin, Audrey" sort="Varin, Audrey" uniqKey="Varin A" first="Audrey" last="Varin">Audrey Varin</name></country><country name="Canada"><noRegion><name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamas" last="Fulop">Tamas Fulop</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Jajte, Jolanta" sort="Jajte, Jolanta" uniqKey="Jajte J" first="Jolanta" last="Jajte">Jolanta Jajte</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Dedoussis, George" sort="Dedoussis, George" uniqKey="Dedoussis G" first="George" last="Dedoussis">George Dedoussis</name></noRegion><name sortKey="Gonos, Efstathios S" sort="Gonos, Efstathios S" uniqKey="Gonos E" first="Efstathios S." last="Gonos">Efstathios S. Gonos</name><name sortKey="Trougakos, Ioannis P" sort="Trougakos, Ioannis P" uniqKey="Trougakos I" first="Ioannis P." last="Trougakos">Ioannis P. Trougakos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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